What is the difference in 1 color and 4 color-process printing? One, two and three color printing is often called "spot colors." One color ink goes on at a time, and the colors are separate and independent of each other--check out our Victory Designs logo above: it is brown and green, 2 "spot colors." Four-color process printing is the "high-end" so to speak...think of a color photograph. All the colors of the spectrum can be attained with cyan, magenta, yellow and black (CMYK.) This is the most expensive way to print because four plates (or set-ups) are needed to print all four colors. Usually full-color process is best for a high quantity job, since the set up charges are absorbed into the cost of the order. This is true for most promotional products as well as screen printing and commercial printing.